Journal: Cancer Management and Research
Article Title: Increased Expression Of SOX2 Predicts A Poor Prognosis And Promotes Malignant Phenotypes In Upper Tract Urothelial Carcinoma
doi: 10.2147/CMAR.S219568
Figure Lengend Snippet: Effect of SOX2 on the migration and invasion of UTUC cells. ( A and B ): The migratory abilities of UTUC cells were determined using a wound healing assay. Cell migration was inhibited by silencing SOX2 in UM-UC-14 and MC-SV-HUC T2 cells. ( C and D ): The invasive abilities of UTUC cells were determined using a transwell assay. Cell invasion was inhibited by silencing SOX2 in UM-UC-14 and MC-SV-HUC T2 cells. Data are shown as the mean ± SD. *p < 0.05; **p < 0.01.
Article Snippet: The UM-UC-14 cell line (Sigma-Aldrich, St. Louis, MO, USA) was a generous gift from Prof. Kitramura of Toyama University, MC-SV-HUC T2 cells were purchased from ATCC (CRL-9519), and SV-HUC-1 cells were purchased from the Institute of Cell Research (Chinese Academy of Sciences, Shanghai, China).
Techniques: Migration, Wound Healing Assay, Transwell Assay